Malignant peripheral nerve sheath tumor arising from an adrenal ganglioneuroma in a 6-year-old boy

Jean-Pierre de Chadarévian; Judy MaePascasio; Gregory E Halligan; Douglas A Katz; Joseph A Locono; Stephen Kimmel; Christos D Katsetos

doi:10.1007/s10024-004-8084-9

Malignant peripheral nerve sheath tumor arising from an adrenal ganglioneuroma in a 6-year-old boy

Pediatr Dev Pathol. 2004 May-Jun;7(3):277-84. doi: 10.1007/s10024-004-8084-9. Epub 2004 Mar 17.

Authors

Jean-Pierre de Chadarévian¹, Judy MaePascasio, Gregory E Halligan, Douglas A Katz, Joseph A Locono, Stephen Kimmel, Christos D Katsetos

Affiliation

¹ Department of Pathology and Laboratory Medicine, St. Christopher's Hospital for Children, and Drexel University College of Medicine, Philadelphia, PA 19134, USA. [email protected]

PMID: 15022069
DOI: 10.1007/s10024-004-8084-9

Abstract

This report describes the youngest patient to develop a malignant peripheral nerve sheath tumor arising from a ganglioneuroma (MPNST ex Ganglioneuroma). The patient, a 6-year-old boy, was never irradiated and had no history or stigmata of neurofibromatosis. The report also includes a review of the previously published related cases, and an analysis of the immunohistochemistry and electron microscopy data available to date on the subject.

Publication types

Case Reports
Review

MeSH terms

Adrenal Gland Neoplasms / pathology*
Adrenal Gland Neoplasms / therapy
Adrenal Gland Neoplasms / urine
Adrenalectomy
Antineoplastic Combined Chemotherapy Protocols
Child
Ganglioneuroma / pathology*
Ganglioneuroma / therapy
Ganglioneuroma / urine
Homovanillic Acid / urine
Humans
Male
Nerve Sheath Neoplasms / pathology*
Nerve Sheath Neoplasms / therapy
Nerve Sheath Neoplasms / urine
Vanilmandelic Acid / urine

Substances

Vanilmandelic Acid
Homovanillic Acid