Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease

J Control Release. 2004 Mar 24;95(3):521-33. doi: 10.1016/j.jconrel.2003.12.018.

Abstract

Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen tablet, containing 20 mg of metronidazole, performed 12 h drug sustained release with buccal concentrations always higher than its MIC.

Publication types

  • Comparative Study

MeSH terms

  • Acrylic Resins / chemistry
  • Acrylic Resins / pharmacokinetics
  • Adhesives / chemistry*
  • Adhesives / pharmacokinetics
  • Animals
  • Cellulose / analogs & derivatives*
  • Cellulose / chemistry
  • Cellulose / pharmacokinetics
  • Chemistry, Pharmaceutical / methods
  • Chemistry, Pharmaceutical / trends
  • Drug Delivery Systems / methods*
  • Drug Delivery Systems / trends*
  • Drug Evaluation, Preclinical / methods
  • Humans
  • Metronidazole / metabolism
  • Metronidazole / pharmacology
  • Metronidazole / therapeutic use*
  • Mouth Mucosa / drug effects
  • Periodontal Diseases / classification
  • Periodontal Diseases / drug therapy*
  • Saliva / chemistry
  • Swine
  • Tablets / chemistry
  • Tablets / pharmacokinetics
  • Time Factors
  • Water / chemistry

Substances

  • Acrylic Resins
  • Adhesives
  • Tablets
  • Water
  • Metronidazole
  • carbopol 940
  • Cellulose
  • hydroxyethylcellulose