Abstract
2,2-dimethyl-4-phenyl-5-[4-(methylsulfinyl)phenyl]-3(2H)furanone derivatives, 3 and 6, were shown to be effectively transformed in vivo into the corresponding methylsulfone derivatives 1 and 4, when orally administered to rats. Pharmacological implications for use of sulfoxide analogues 3 and 6 are discussed as prodrugs to potent selective COX-2 inhibitors 1 and 4.
MeSH terms
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Animals
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Cyclooxygenase Inhibitors / administration & dosage*
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Cyclooxygenase Inhibitors / chemistry
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Dimethyl Sulfoxide
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Dose-Response Relationship, Drug
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Male
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Prodrugs / administration & dosage*
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Prodrugs / chemistry
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Rats
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Rats, Inbred Lew
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Rats, Sprague-Dawley
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Sulfones / administration & dosage*
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Sulfones / chemistry
Substances
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Cyclooxygenase Inhibitors
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Prodrugs
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Sulfones
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dimethyl sulfone
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Dimethyl Sulfoxide