Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists

Nagaaki Sato; Takunobu Shibata; Makoto Jitsuoka; Toshiyuki Ohno; Toshiyuki Takahashi; Tomoko Hirohashi; Tetsuya Kanno; Hisashi Iwaasa; Akio Kanatani; Takehiro Fukami

doi:10.1016/j.bmcl.2004.01.049

Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1761-4. doi: 10.1016/j.bmcl.2004.01.049.

Authors

Nagaaki Sato¹, Takunobu Shibata, Makoto Jitsuoka, Toshiyuki Ohno, Toshiyuki Takahashi, Tomoko Hirohashi, Tetsuya Kanno, Hisashi Iwaasa, Akio Kanatani, Takehiro Fukami

Affiliation

¹ Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan. [email protected]

PMID: 15026066
DOI: 10.1016/j.bmcl.2004.01.049

Abstract

A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.

MeSH terms

Aminopyridines / chemistry*
Aminopyridines / metabolism
Aminopyridines / pharmacology
Animals
CHO Cells
Cricetinae
Drug Evaluation, Preclinical / methods
Humans
Receptors, Neuropeptide Y / antagonists & inhibitors*
Receptors, Neuropeptide Y / metabolism

Substances

Aminopyridines
Receptors, Neuropeptide Y
neuropeptide Y-Y1 receptor