Abstract
Immune regulation plays an important role in the establishment and maintenance of self-tolerance. Nevertheless, it has been difficult to conclude whether regulation is Ag specific because studies have focused on polyclonal populations of regulatory T cells. We have used in this study a murine transgenic model that generates self-reactive, regulatory T cells of known Ag specificity to determine their capacity to suppress naive T cells specific for other Ags. We show that these regulatory cells can regulate the responses of naive T cells with the same TCR specificity, but do not inhibit T cell proliferation or differentiation of naive T cells specific for other Ags. These results demonstrate that immune regulation may be more Ag specific than previously proposed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoantigens / genetics
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Autoantigens / immunology*
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Bystander Effect / genetics
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Bystander Effect / immunology
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Cell Differentiation / genetics
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Cell Differentiation / immunology
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Cell Division / genetics
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Cell Division / immunology
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Cytokines / antagonists & inhibitors
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Cytokines / biosynthesis
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology*
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Interphase / genetics
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Interphase / immunology
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Mice
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Mice, Inbred BALB C
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Mice, Transgenic
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / physiology
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Receptors, Interleukin-2 / biosynthesis
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Ribonucleoproteins / genetics
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Ribonucleoproteins / immunology
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SS-B Antigen
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism*
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T-Lymphocytes, Helper-Inducer / cytology
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T-Lymphocytes, Helper-Inducer / immunology
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T-Lymphocytes, Helper-Inducer / metabolism
Substances
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Autoantigens
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Cytokines
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Epitopes, T-Lymphocyte
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Interleukin-2
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Ribonucleoproteins