The aesthetic applications of botulinum toxin A (Botox) are well known to certain medical and nonmedical communities. This nonsurgical rejuvenation modality continues to be in high demand in part because of the immediacy of its effects, its high safety profile, and its no-downtime recovery period. The physician interested in using Botox for facial rejuvenation needs to have a working knowledge of facial anatomy and botulinum toxin pharmacology and clinical experience with Botox injections.