Cranial nerve palsies in metastatic prostate cancer--results of base of skull radiotherapy

Joe M O'Sullivan; Andrew R Norman; Helen McNair; David P Dearnaley

doi:10.1016/j.radonc.2003.10.007

Cranial nerve palsies in metastatic prostate cancer--results of base of skull radiotherapy

Radiother Oncol. 2004 Jan;70(1):87-90. doi: 10.1016/j.radonc.2003.10.007.

Authors

Joe M O'Sullivan¹, Andrew R Norman, Helen McNair, David P Dearnaley

Affiliation

¹ Academic Unit of Radiotherapy and Clinical Oncology, Institute of Cancer Research/Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK.

PMID: 15036857
DOI: 10.1016/j.radonc.2003.10.007

Abstract

We studied the rate of response to palliative external beam radiation therapy (20 Gy/5 or 30 Gy/10 fractions) to the base of skull in 32 prostate cancer patients with cranial nerve dysfunction. Sixteen patients (50%; 95% CI, 34-66%) had a useful response to therapy. The median survival post-therapy was 3 months.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cranial Nerve Diseases / drug therapy
Cranial Nerve Diseases / etiology*
Dexamethasone / therapeutic use
Glucocorticoids / therapeutic use
Humans
Logistic Models
Male
Middle Aged
Prostatic Neoplasms / mortality
Prostatic Neoplasms / pathology*
Radiation Dosage
Skull Base Neoplasms / complications
Skull Base Neoplasms / mortality
Skull Base Neoplasms / radiotherapy*
Skull Base Neoplasms / secondary
Treatment Outcome

Substances

Glucocorticoids
Dexamethasone