Devic disease and thymoma with anti-central nervous system and antithymus antibodies

Neurology. 2004 Mar 23;62(6):978-80. doi: 10.1212/01.wnl.0000115168.73299.88.

Abstract

A patient with myasthenia gravis and thymoma developed neuromyelitis optica (NMO) and necrotizing myositis 4 months after treatment of the tumor. Antibodies reacting with the CNS and thymic epithelial cells were detected in the serum during the acute phase of NMO, suggesting that the NMO was linked to the thymoma.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Autoantibodies / blood*
  • Central Nervous System / immunology*
  • Cerebellum / immunology
  • Humans
  • Immunohistochemistry
  • Immunologic Tests
  • Male
  • Middle Aged
  • Myasthenia Gravis / complications
  • Myasthenia Gravis / diagnosis
  • Myasthenia Gravis / immunology
  • Myositis / complications
  • Myositis / diagnosis
  • Myositis / immunology
  • Neuromyelitis Optica / complications
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / immunology*
  • Plasma Exchange
  • Rats
  • Spinal Cord / immunology
  • Thymoma / complications
  • Thymoma / diagnosis
  • Thymoma / immunology*
  • Thymus Gland / immunology*
  • Thymus Gland / pathology
  • Thymus Neoplasms / complications
  • Thymus Neoplasms / diagnosis
  • Thymus Neoplasms / immunology*

Substances

  • Autoantibodies