Abstract
Helicobacter pylori-infected subjects exhibited a strong decline in antral secretory leukocyte protease inhibitor (SLPI) levels compared to H. pylori-negative subjects and subjects from whom H. pylori had been eradicated (P = 0.002). This reduction was specific for the antrum, whereas SLPI expression in corpus and duodenum was not affected. Antral SLPI levels were inversely correlated with inflammatory scores of antrum-predominant gastritis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Down-Regulation*
-
Female
-
Gastritis / microbiology
-
Gastritis / physiopathology*
-
Helicobacter Infections / physiopathology
-
Helicobacter pylori / pathogenicity*
-
Humans
-
Immunohistochemistry
-
Male
-
Proteinase Inhibitory Proteins, Secretory
-
Proteins / metabolism*
-
Pyloric Antrum / metabolism*
-
Secretory Leukocyte Peptidase Inhibitor
Substances
-
Proteinase Inhibitory Proteins, Secretory
-
Proteins
-
SLPI protein, human
-
Secretory Leukocyte Peptidase Inhibitor