Abstract
The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to 0.06 microg/ml for penicillin-susceptible streptococci (n = 132), and from 1 to 4 microg/ml for penicillin-resistant streptococci (n = 51). Overall, doripenem demonstrated in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Carbapenems / pharmacology*
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Cephalosporins / pharmacology
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Doripenem
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Drug Therapy, Combination / pharmacology
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Enterobacteriaceae / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Penicillanic Acid / analogs & derivatives*
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Penicillanic Acid / pharmacology
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Penicillin Resistance
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Penicillins / pharmacology
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Piperacillin / pharmacology
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Tazobactam
Substances
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Anti-Bacterial Agents
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Carbapenems
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Cephalosporins
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Penicillins
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Penicillanic Acid
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Doripenem
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Tazobactam
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Piperacillin