Abstract
Mutations selected or deselected during passage of human immunodeficiency virus strain HXB2 or resistant variants with tenofovir (TFV), abacavir (ABC), and lamivudine (3TC) differed depending on the drug combination and virus genotype. In the wild-type virus, TFV-ABC and TFV-3TC selected K65R (with reduced susceptibility to all three inhibitors) and then Y115F. TFV-containing regimens might increase K65R selection, which confers multiple nucleoside reverse transcriptase inhibitor resistance.
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / pharmacology*
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Anti-HIV Agents / pharmacology*
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Cloning, Molecular
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Dideoxynucleosides / pharmacology*
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Drug Combinations
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Drug Resistance, Viral
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Genotype
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HIV / drug effects
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HIV Reverse Transcriptase / genetics*
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Humans
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Lamivudine / pharmacology*
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Mutation / genetics
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Organophosphonates*
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Organophosphorus Compounds / pharmacology*
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Reverse Transcriptase Inhibitors / pharmacology*
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Tenofovir
Substances
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Anti-HIV Agents
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Dideoxynucleosides
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Drug Combinations
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Organophosphonates
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Organophosphorus Compounds
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Reverse Transcriptase Inhibitors
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Lamivudine
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Tenofovir
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HIV Reverse Transcriptase
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Adenine
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abacavir