Allogeneic transplantation: a therapeutic option for myelofibrosis, chronic myelomonocytic leukemia and Philadelphia-negative/BCR-ABL-negative chronic myelogenous leukemia

Bone Marrow Transplant. 2004 May;33(10):1005-9. doi: 10.1038/sj.bmt.1704472.

Abstract

The role of allogeneic transplantation for myeloproliferative diseases other than chronic myeloid leukemia is not well established. In all, 20 patients with a median age of 51 years underwent allogeneic hematopoietic stem cell transplantation (HSCT) for myelofibrosis (n=5), chronic myelomonocytic leukemia (CMML) (n=8) and Philadelphia (Ph) chromosome-negative/BCR-ABL-negative chronic myeloid leukemia (CML) (n=7) in our institution. Patients who developed acute leukemia prior to HSCT were excluded from this analysis. A total of 15 patients received related and five patients received unrelated donor transplants. One patient failed to engraft. After a median follow-up of 17.5 months, actuarial survival at 2 years was 47% (95% CI 2%-67%), and disease-free survival 37% (95% CI 17-58%). Allogeneic transplantation may provide a therapeutic option for patients with myelofibrosis, CMML and Ph chromosome-negative/BCR-ABL-negative CML.

MeSH terms

  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Fusion Proteins, bcr-abl / metabolism*
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation / methods*
  • Histocompatibility Testing
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / therapy*
  • Leukemia, Myelomonocytic, Chronic / therapy*
  • Male
  • Middle Aged
  • Primary Myelofibrosis / therapy*
  • Time Factors
  • Transplantation Conditioning
  • Transplantation, Homologous / methods*
  • Treatment Outcome

Substances

  • Fusion Proteins, bcr-abl