Structures of the lectins from Pseudomonas aeruginosa: insight into the molecular basis for host glycan recognition

Anne Imberty; Michaela wimmerová; Edward P Mitchell; Nechama Gilboa-Garber

doi:10.1016/j.micinf.2003.10.016

Structures of the lectins from Pseudomonas aeruginosa: insight into the molecular basis for host glycan recognition

Microbes Infect. 2004 Feb;6(2):221-8. doi: 10.1016/j.micinf.2003.10.016.

Authors

Anne Imberty¹, Michaela wimmerová, Edward P Mitchell, Nechama Gilboa-Garber

Affiliation

¹ CERMAV--CNRS, Grenoble, France. [email protected]

PMID: 15049333
DOI: 10.1016/j.micinf.2003.10.016

Abstract

The opportunistic human pathogen Psuedomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL adn PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adhesins, Bacterial / chemistry
Adhesins, Bacterial / immunology*
Glycoproteins / chemistry
Glycoproteins / metabolism*
Lectins / chemistry
Lectins / immunology*
Pseudomonas aeruginosa / immunology
Pseudomonas aeruginosa / metabolism*
Receptors, Immunologic / immunology

Substances

Adhesins, Bacterial
Glycoproteins
Lectins
Receptors, Immunologic
adhesin, Pseudomonas