Abstract
The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.
MeSH terms
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Chromosomes, Human, Pair 21 / genetics*
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Chromosomes, Human, Pair 8 / genetics*
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins / genetics
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / physiology
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Proto-Oncogene Proteins / genetics
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RUNX1 Translocation Partner 1 Protein
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Signal Transduction
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Transcription Factors / genetics
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Transcription, Genetic
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Translocation, Genetic
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / physiology*
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ras Proteins / genetics
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ras Proteins / metabolism
Substances
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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Oncogene Proteins, Fusion
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Proto-Oncogene Proteins
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RUNX1 Translocation Partner 1 Protein
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RUNX1 protein, human
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RUNX1T1 protein, human
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Transcription Factors
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins
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ras Proteins