Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension

Methods Enzymol. 2004:381:121-9. doi: 10.1016/S0076-6879(04)81007-3.

Authors

Larissa A Shimoda¹, Gregg L Semenza

Affiliation

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkinds University School of Medicine, Baltimore, Maryland 21224, USA.

PMID: 15063669
DOI: 10.1016/S0076-6879(04)81007-3

No abstract available

MeSH terms

Animals
Blood Pressure / physiology
Clinical Laboratory Techniques*
DNA-Binding Proteins / physiology*
Heart Ventricles / metabolism
Hematocrit
Hypertension, Pulmonary / etiology*
Hypoxia / metabolism*
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Male
Mice
Mice, Inbred C57BL
Myocytes, Smooth Muscle / metabolism
Nuclear Proteins / physiology*
Patch-Clamp Techniques / methods
Pulmonary Artery / metabolism
Transcription Factors*

Substances

DNA-Binding Proteins
Hif1a protein, mouse
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Nuclear Proteins
Transcription Factors