Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity

Methods Enzymol. 2004:381:218-29. doi: 10.1016/S0076-6879(04)81016-4.

Authors

Hidefumi Kojima¹, Brendan T Jones, Jianzhu Chen, Marilia Cascalho, Michail V Sitkovsky

Affiliation

¹ Division on Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan.

PMID: 15063678
DOI: 10.1016/S0076-6879(04)81016-4

No abstract available

MeSH terms

Animals
Autoantibodies / immunology
Autoimmunity / immunology*
B-Lymphocytes / immunology
B-Lymphocytes / physiology*
Cell Differentiation / immunology
Cell Differentiation / physiology*
Chimera
DNA / immunology
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Gene Targeting / methods*
Hypoxia-Inducible Factor 1, alpha Subunit
Mice
Mice, Knockout
Proteinuria / metabolism
T-Lymphocytes / immunology
T-Lymphocytes / physiology
Transcription Factors / deficiency
Transcription Factors / genetics*

Substances

Autoantibodies
DNA-Binding Proteins
Hypoxia-Inducible Factor 1, alpha Subunit
Rag2 protein, mouse
Transcription Factors
V(D)J recombination activating protein 2
DNA