[A possible preneoplastic lesion of colorectum]

Mao-de Lai; Qiong Huang; Reza Parwaresch

doi:10.3785/j.issn.1008-9292.2004.02.005

[A possible preneoplastic lesion of colorectum]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Mar;33(2):115-7. doi: 10.3785/j.issn.1008-9292.2004.02.005.

[Article in Chinese]

Authors

Mao-de Lai¹, Qiong Huang, Reza Parwaresch

Affiliation

¹ Department of Pathology and Pathophysiology, Center for Environmental Genomics, College of Medicine, Zhejiang University, Hangzhou 310031, China. [email protected]

PMID: 15067729
DOI: 10.3785/j.issn.1008-9292.2004.02.005

Abstract

Objective: To investigate KiA10 expression in colorectal cancer and related colorectal tissues.

Methods: KiA10 expression was detected by immunohistochemistry in tissue specimens from 101 cases of colorectal cancer and matched cut-margin mucosa and mucosa adjacent to cancers; also in colorectal specimens from 16 cases of ulcerative colitis, 16 of Crohn's disease and 3 healthy subjects.

Result: The positive rate of KiA10 expression in colorectal cancer was 14.85% (15/101); KiA10 positive crypts was demonstrated in 18 cut-margin mucosa and 18 mucosa adjacent to tumors respectively, but they were not matched with each other.

Conclusion: The results suggest that KiA10-positive crypts of the colon might be a preneoplastic lesion.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Antigens, Nuclear / analysis*
Biomarkers, Tumor / analysis*
Colorectal Neoplasms / pathology*
Female
Humans
Immunohistochemistry
Male
Middle Aged
Precancerous Conditions / pathology*

Substances

Antigens, Nuclear
Biomarkers, Tumor