Abstract
Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH. Mediation of this regulation by the transcriptional regulator PacC has been confirmed via acidity- and alkalinity-mimicking mutants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus nidulans / genetics
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Aspergillus nidulans / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Fungal Proteins / physiology*
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Gene Expression Regulation, Fungal / genetics
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Hydrogen-Ion Concentration
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Iron / metabolism
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Mutation
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Siderophores / biosynthesis
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Siderophores / genetics
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Siderophores / metabolism*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription Factors / physiology*
Substances
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Fungal Proteins
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PacC protein, Aspergillus
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Siderophores
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Transcription Factors
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Iron