Abstract
Neuropeptide Y (NPY) has been implicated in antiepileptic action in different in vivo and in vitro epilepsy models in rats and mice. Both Y2 and Y5 receptors could mediate the seizure-suppressant effect of NPY. However, lack of selective ligands precluded previous studies from conclusively evaluating the role of Y5 receptors in anti-epileptiform action of NPY. In the present study, using the new highly selective Y5 receptor antagonist, CGP71683A, and agonist, [cPP]hPP, we show that the Y5 receptor subtype is centrally involved in NPY-induced suppression of spontaneous epileptiform (interictaform) bursting in the CA3 area of rat hippocampal slices. This novel finding underscores the importance of Y5 receptors as a potential target for future antiepileptic therapy, particularly, for interictal components of temporal lobe epilepsy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Animals
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Anticonvulsants / pharmacology
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Epilepsy, Temporal Lobe / drug therapy
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Epilepsy, Temporal Lobe / metabolism
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Epilepsy, Temporal Lobe / physiopathology*
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Female
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Hippocampus / cytology
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Hippocampus / drug effects
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Hippocampus / physiopathology*
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In Vitro Techniques
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Magnesium Deficiency / metabolism
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Male
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Naphthalenes / pharmacology
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Neurons / drug effects
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Neurons / metabolism
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Neuropeptide Y / analogs & derivatives
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Neuropeptide Y / metabolism*
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Pyrimidines / pharmacology
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Rats
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Rats, Wistar
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Receptors, Neuropeptide Y / agonists
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Receptors, Neuropeptide Y / antagonists & inhibitors
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Receptors, Neuropeptide Y / metabolism*
Substances
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Anticonvulsants
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Naphthalenes
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Neuropeptide Y
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Pyrimidines
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Receptors, Neuropeptide Y
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neuropeptide Y5 receptor
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CGP 71683 A