Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis

Bioorg Med Chem. 2004 May 1;12(9):2193-7. doi: 10.1016/j.bmc.2004.02.020.

Abstract

The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9'-O-feruloyl-(-)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC(50) values of 1.8 and 3.9 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Esters
  • Hibiscus / chemistry*
  • Humans
  • Phenylpropionates / chemistry
  • Phenylpropionates / isolation & purification
  • Phenylpropionates / pharmacology*
  • Plant Stems / chemistry*
  • Spectrum Analysis

Substances

  • Esters
  • Phenylpropionates