Abstract
Noncontact optical measurements from diffuse media could facilitate the use of large detector arrays at multiple angles that are well suited for diffuse optical tomography applications. Such imaging strategy could eliminate the need for individual fibers in contact with tissue, restricted geometries, and matching fluids. Thus, it could significantly improve experimental procedures and enhance our ability to visualize functional and molecular processes in vivo. In this paper, we describe the experimental implementation of this novel concept and demonstrate capacity to perform small animal imaging.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Validation Study
MeSH terms
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Algorithms*
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Animals
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Equipment Design
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Equipment Failure Analysis
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Esophagus / anatomy & histology*
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Feasibility Studies
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Humans
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Image Interpretation, Computer-Assisted / instrumentation
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Image Interpretation, Computer-Assisted / methods*
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Imaging, Three-Dimensional / instrumentation
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Imaging, Three-Dimensional / methods*
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Mice
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Microscopy, Fluorescence / instrumentation*
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Microscopy, Fluorescence / methods*
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Phantoms, Imaging
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Reproducibility of Results
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Sensitivity and Specificity
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Tomography / instrumentation*
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Tomography / methods*