Mapping quantitative traits with random and with ascertained sibships

Proc Natl Acad Sci U S A. 2004 May 25;101(21):7845-50. doi: 10.1073/pnas.0401713101. Epub 2004 Apr 14.

Abstract

Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping / methods*
  • Female
  • Humans
  • Male
  • Pedigree
  • Quantitative Trait Loci / genetics*
  • Quantitative Trait, Heritable*
  • Regression Analysis
  • Siblings*