Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids

Wound Repair Regen. 2004 Mar-Apr;12(2):169-74. doi: 10.1111/j.1067-1927.2004.012209.x.

Abstract

Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin-1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin-1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin-1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Cicatrix, Hypertrophic / metabolism*
  • Cicatrix, Hypertrophic / pathology
  • Elastin / metabolism*
  • Female
  • Fibrillin-1
  • Fibrillins
  • Humans
  • Keloid / metabolism*
  • Keloid / pathology
  • Male
  • Microfilament Proteins / metabolism*
  • Middle Aged
  • Skin / metabolism*
  • Skin / pathology
  • Wound Healing / physiology

Substances

  • FBN1 protein, human
  • Fibrillin-1
  • Fibrillins
  • Microfilament Proteins
  • Elastin