Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy

J Neuroimaging. 2004 Apr;14(2):133-8.

Abstract

Continuous arterial spin labeling perfusion magnetic resonance imaging (CASL-pMRI) uses magnetically labeled arterial blood water as a tracer to obtain quantifiable measurements of cerebral blood flow (CBF) (mL/100 g-1/min-1). CASL-pMRI was used to assess CBF changes in major vascular distributions in patients (n = 10) prior to and 3 months after carotid endarterectomy (CEA). No significant change in the global baseline CBF before and after CEA was observed in the group as a whole (P = .81). In patients with reduced CBF prior to CEA (< 50 ml/100 g/min), a significant increase in global CBF following CEA was observed. An inverse relationship existed between percent change in CBF after CEA versus baseline CBF within the anterior circulation (r = -.78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Flow Velocity / physiology
  • Brain / blood supply*
  • Brain Ischemia / diagnosis*
  • Brain Ischemia / surgery
  • Carotid Stenosis / diagnosis*
  • Carotid Stenosis / physiopathology
  • Carotid Stenosis / surgery
  • Cerebral Infarction / diagnosis
  • Cerebral Infarction / physiopathology
  • Cerebral Infarction / surgery
  • Endarterectomy, Carotid*
  • Female
  • Follow-Up Studies
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted / methods*
  • Ischemic Attack, Transient / diagnosis
  • Ischemic Attack, Transient / physiopathology
  • Ischemic Attack, Transient / surgery
  • Magnetic Resonance Angiography / methods*
  • Male
  • Middle Aged
  • Neurologic Examination
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / physiopathology
  • Regional Blood Flow / physiology
  • Reperfusion Injury / diagnosis*
  • Reperfusion Injury / physiopathology
  • Sensitivity and Specificity
  • Treatment Outcome