The experimental energy dependence of the electron paramagnetic resonance (EPR) radiation-induced signal at irradiation by photons in the energy range of 13 keV-1.25 MeV was analysed in terms of the absorbed dose in human tooth enamel. The latter was calculated using a Monte Carlo simulation of the photon and electron transport. The dependence of the calculated absorbed dose on the sample thickness was analysed. No energy dependence of the EPR signal on the absorbed dose in enamel was verified in the range of 37 keV-1.25 MeV. At 13 and 20 keV the EPR signal dose response was reduced by 8% probably due to sample powdering. Dose-depth profiles in enamel samples irradiated by 1.25 MeV photons in polymethylmethacrylate and aluminium build-up materials were calculated. It was concluded that secondary electron equilibrium conditions are better fulfilled for irradiation in aluminium, which makes this material preferable for calibration.