Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

Annette Angell; Christopher McGuigan; Luis Garcia Sevillano; Robert Snoeck; Graciela Andrei; Erik De Clercq; Jan Balzarini

doi:10.1016/j.bmcl.2004.03.029

Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

Bioorg Med Chem Lett. 2004 May 17;14(10):2397-9. doi: 10.1016/j.bmcl.2004.03.029.

Authors

Annette Angell¹, Christopher McGuigan, Luis Garcia Sevillano, Robert Snoeck, Graciela Andrei, Erik De Clercq, Jan Balzarini

Affiliation

¹ Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

PMID: 15109620
DOI: 10.1016/j.bmcl.2004.03.029

Abstract

Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic / pharmacology
Herpesvirus 3, Human / drug effects*
Microbial Sensitivity Tests
Nucleosides / chemical synthesis*
Nucleosides / pharmacology
Structure-Activity Relationship

Substances

Antiviral Agents
Bridged Bicyclo Compounds, Heterocyclic
Nucleosides