Abstract
The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology*
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Disease Susceptibility
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Genes, MHC Class I*
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Genes, MHC Class II*
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / genetics
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Histocompatibility Antigens Class I / physiology
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Histocompatibility Antigens Class II / chemistry
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Histocompatibility Antigens Class II / genetics
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Histocompatibility Antigens Class II / physiology
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Humans
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Immunity, Innate*
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Infections / genetics
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Infections / immunology*
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Polymorphism, Genetic*
Substances
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II