A biventricular assistance device has been implanted in a young woman for a peripartum cardiac failure. An intended weaning consisted of gradual reloading and exercise training monitored with peak oxygen consumption (VO(2)) and radionuclide-left ventricle ejection fraction. Progressive increase in peak VO(2) during partial assistance occurred more than 2 months, from 10.3 to 19 mL.kg(-1).min(-1). Successful explantation was realized when peak VO(2) exceeded 15 mL.kg(-1).min(-1) and radionuclide-left ventricle ejection fraction was more than 40% during off-pump testing.