Abstract
In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, CD
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CD11c Antigen / analysis
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Carcinoembryonic Antigen
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Cell Adhesion Molecules
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Cell Line
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Cells, Cultured
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Dendritic Cells / virology*
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Glycoproteins / physiology*
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Mice
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Mice, Inbred BALB C
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Murine hepatitis virus / pathogenicity*
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Receptors, Virus / physiology*
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T-Lymphocytes / immunology
Substances
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Antigens, CD
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CD11c Antigen
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CD66 antigens
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Carcinoembryonic Antigen
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Ceacam1 protein, mouse
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Cell Adhesion Molecules
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Glycoproteins
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Receptors, Virus