Abstract
Five new ent-kauranoids, xindongnins C - G ( 1 - 5), together with five known ones, xindongnins A and B ( 6 and 7), melissoidesin G ( 8), dawoensin A ( 9), and glabcensin V ( 10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6 - 10 showed inhibitory effects against human tumor K562 cells with IC (50) values ranging from 0.3 to 7.3 microg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.
MeSH terms
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Diterpenes, Kaurane / administration & dosage
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / pharmacology*
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Diterpenes, Kaurane / therapeutic use
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Humans
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Inhibitory Concentration 50
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Isodon*
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K562 Cells / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Kaurane
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Plant Extracts