Neuropsychological executive functioning in children at elevated risk for alcoholism: findings in early adolescence

J Abnorm Psychol. 2004 May;113(2):302-14. doi: 10.1037/0021-843X.113.2.302.

Abstract

One component of individual risk for alcoholism may involve cognitive vulnerabilities prodromal to alcoholism onset. This prospective study of 198 boys followed between 3 and 14 years of age evaluated neurocognitive functioning across three groups who varied in familial risk for future alcoholism. Measures of intelligence, reward-response, and a battery of neuropsychological executive and cognitive inhibitory measures were used. Executive functioning weaknesses were greater in families with alcoholism but no antisocial comorbidity. IQ and reward-response weaknesses were associated with familial antisocial alcoholism. Executive function effects were clearest for response inhibition, response speed, and symbol-digit modalities. Results suggest that executive deficits are not part of the highest risk, antisocial pathway to alcoholism but that some executive function weaknesses may contribute to a secondary risk pathway.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Alcoholism / epidemiology*
  • Child
  • Child of Impaired Parents / statistics & numerical data*
  • Cognition Disorders / epidemiology*
  • Humans
  • Neuropsychological Tests
  • Prospective Studies
  • Reaction Time
  • Risk Factors
  • Severity of Illness Index
  • Surveys and Questionnaires