Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Yousang Hwang; Philip A Cole

doi:10.1021/ol049714v

Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Org Lett. 2004 May 13;6(10):1555-6. doi: 10.1021/ol049714v.

Authors

Yousang Hwang¹, Philip A Cole

Affiliation

¹ Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe St. Baltimore, Maryland 21205, USA.

PMID: 15128234
DOI: 10.1021/ol049714v

Abstract

An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Molecular Structure
Organophosphorus Compounds / chemistry*
Pentanoic Acids / chemistry*
Phosphorylation
Prodrugs / chemical synthesis*

Substances

Organophosphorus Compounds
Pentanoic Acids
Prodrugs
bis-pivaloyloxymethyl phosphate