Development of an indole safety-catch linker using analytical constructs

Jan J Scicinski; Miles S Congreve; Steven V Ley

doi:10.1021/cc0499791

Development of an indole safety-catch linker using analytical constructs

J Comb Chem. 2004 May-Jun;6(3):375-84. doi: 10.1021/cc0499791.

Authors

Jan J Scicinski¹, Miles S Congreve, Steven V Ley

Affiliation

¹ GlaxoSmithKline Cambridge Chemistry Laboratory and Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. [email protected]

PMID: 15132597
DOI: 10.1021/cc0499791

Abstract

The development, evaluation, and application of a novel safety-catch linker for solid-phase synthesis based on an N-tosylindole is reported. The development of this linker using analytical constructs to aid analysis is discussed.