Mass spectrometry and DNA sequencing are complementary techniques for characterizing hemoglobin variants: the example of hemoglobin J-Oxford

Haematologica. 2004 May;89(5):608-9.

Abstract

Liquid chromatography-electrospray ionization-mass spectrometry (MS) allows the characterization of most hemoglobin variants and can sometimes be a useful tool to narrow down DNA sequencing analysis. As an example, we report a case of hemoglobin variant J-Oxford, characterized by MS and DNA sequencing analysis.

Publication types

  • Letter

MeSH terms

  • Adult
  • Codon / genetics
  • Female
  • Hemoglobin J / chemistry*
  • Hemoglobin J / genetics
  • Humans
  • Mutation
  • Sequence Analysis, DNA*
  • Spectrometry, Mass, Electrospray Ionization*

Substances

  • Codon
  • Hemoglobin J
  • hemoglobin I-Interlaken