Abstract
The current standard of care for the treatment of anal cancer as demonstrated by all of the completed phase 3 clinical trials remains 5-FU and mitomycin C in combination with radiation therapy. The basic elements of the approach outlined by Nigro have not changed in the last 30 years. Future phase 3 trials will serve to further perfect this approach and outline the role of HPV and dysplasia in the development and progression of this disease.
MeSH terms
-
Antibiotics, Antineoplastic / administration & dosage
-
Antimetabolites, Antineoplastic / administration & dosage
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Anus Neoplasms / radiotherapy
-
Anus Neoplasms / therapy*
-
Clinical Trials as Topic*
-
Clinical Trials, Phase III as Topic
-
Combined Modality Therapy
-
Fluorouracil / administration & dosage
-
Humans
-
Mitomycin / administration & dosage
Substances
-
Antibiotics, Antineoplastic
-
Antimetabolites, Antineoplastic
-
Mitomycin
-
Fluorouracil