The phenomenon of sonoluminescence has been known for over 60 years but it is only over the last few years that a better understanding of its origins has emerged. In part the discovery of single bubble sonoluminescence, just over 10 years ago, has been a major contributor to the theoretical advances that have been made to account for the event. This Minireview is from the perspective of a physical chemist and considers the progress that has been made in understanding the role of solutes in affecting the sonoluminescence from a solution exposed to ultrasound. The physicochemical properties of solutes that are important in controlling both single bubble and multibubble sonoluminescence are discussed.