Design, synthesis, and biological activity of novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives

Chang-Ling Liu; Lin Li; Zheng-Ming Li

doi:10.1016/j.bmc.2004.03.050

Design, synthesis, and biological activity of novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives

Bioorg Med Chem. 2004 Jun 1;12(11):2825-30. doi: 10.1016/j.bmc.2004.03.050.

Authors

Chang-Ling Liu¹, Lin Li, Zheng-Ming Li

Affiliation

¹ Agrochemical Discovery Department, Shenyang Research Institute of Chemical Industry, Shenyang 110021, China. [email protected]

PMID: 15142542
DOI: 10.1016/j.bmc.2004.03.050

Abstract

Novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives (11-23) were synthesized from 3,4-dimethoxyacetophenone (5) in six-step procedure. Their biological activities were evaluated in the greenhouse. Some of the compounds had shown fungicidal and insecticidal activities at 375 g ai/ha and 600 g ai/ha, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Carboxylic Acids / chemistry*
Insecticides / chemical synthesis*
Insecticides / chemistry
Insecticides / pharmacology*
Thiazoles / chemical synthesis*
Thiazoles / chemistry
Thiazoles / pharmacology*

Substances

Antifungal Agents
Carboxylic Acids
Insecticides
Thiazoles