Abstract
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.
MeSH terms
-
Anti-Allergic Agents / chemistry*
-
Anti-Allergic Agents / metabolism
-
Anti-Allergic Agents / therapeutic use
-
Benzimidazoles / chemistry*
-
Benzimidazoles / metabolism
-
Benzimidazoles / therapeutic use
-
Binding, Competitive / drug effects
-
Humans
-
Protein Binding / drug effects
-
Radioligand Assay
-
Receptors, Immunologic
-
Receptors, Prostaglandin / antagonists & inhibitors*
-
Receptors, Prostaglandin / metabolism
-
Rhinitis, Allergic, Perennial / drug therapy*
-
Rhinitis, Allergic, Perennial / metabolism
Substances
-
Anti-Allergic Agents
-
Benzimidazoles
-
Receptors, Immunologic
-
Receptors, Prostaglandin
-
prostaglandin D2 receptor