The effects of backscattered radiation on the dosimetric response of the Varian aS500 amorphous silicon electronic portal imaging device (EPID) are studied. Measurements demonstrate that radiation backscattered from the EPID mechanical support structure causes 5% asymmetries in the detected signal. To minimize the effect of backscattered radiation from the support structure, this work proposes adding material downstream of the EPID phosphor which provides uniform backscattering material to the phosphor and attenuates backscatter from the support structure before it reaches the phosphor. Two material locations were studied: downstream of the existing image cassette and within the cassette, immediately downstream of the flat-panel imager glass panel. Monte Carlo simulations were used to determine the thicknesses of water, Pb and Cu backscattering materials required to saturate the backscattered signal response for 6 MV and 18 MV beams for material thicknesses up to 50 mm. Water was unable to saturate the backscattered signal for thicknesses up to 50 mm for both energies. For Pb, to obtain a signal within 1% of saturation, 3 mm was required at 6 MV, and 6.8 mm was required at 18 MV. For Cu, thicknesses of 20.6 mm and 22.6 mm were required for the 6 MV and 18 MV beams, respectively. For saturation thicknesses, at 6 MV, the Cu backscatter enhanced the signal more than for Pb (Cu 1.25, Pb 1.11), but at 18 MV the reverse was found (Cu 1.19, Pb 1.23). This is due to the fact that at 6 MV, the backscattered radiation signal is dominated by low-energy scattered photons, which are readily attenuated by the Pb, while at 18 MV, electron backscatter contributes substantially to the signal. Image blurring caused by backscatter spread was less for Pb than Cu. Placing Pb immediately downstream of the glass panel further reduced the signal spread and increased the backscatter enhancement to 1.20 and 1.39 for the 6 MV and 18 MV beams, respectively. Overall, it is determined that adding approximately 5 mm of Pb between the detector and the mechanical support structure will substantially reduce the nonuniformity in the backscattered signals for 6 MV and 18 MV photon beams.