Innate immune recognition of microbes through Nod1 and Nod2: implications for disease

Leticia A M Carneiro; Leonardo H Travassos; Dana J Philpott

doi:10.1016/j.micinf.2004.01.012

Innate immune recognition of microbes through Nod1 and Nod2: implications for disease

Microbes Infect. 2004 May;6(6):609-16. doi: 10.1016/j.micinf.2004.01.012.

Authors

Leticia A M Carneiro¹, Leonardo H Travassos, Dana J Philpott

Affiliation

¹ Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, avenue 28-de Setembro, 87-Fundos-3(o) andar, 20550-030 Rio de Janeiro, Brazil.

PMID: 15158196
DOI: 10.1016/j.micinf.2004.01.012

Abstract

Nod1 and Nod2 are cytosolic proteins involved in intracellular recognition of microbes and their products. Recently, it was shown that these proteins recognize different moieties of bacterial peptidoglycan (PGN) mediating non-specific pathogen resistance and possibly generating signals for the adaptive immune response. Moreover, mutations in the gene encoding Nod2 are associated with increased susceptibility to chronic inflammatory disorders.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptor Proteins, Signal Transducing / immunology*
Apoptosis
Bacteria / chemistry
Bacteria / immunology*
Humans
Immunity, Innate*
Inflammation
Intracellular Signaling Peptides and Proteins / immunology*
Nod1 Signaling Adaptor Protein
Nod2 Signaling Adaptor Protein
Peptidoglycan / immunology
Peptidoglycan / metabolism

Substances

Adaptor Proteins, Signal Transducing
Intracellular Signaling Peptides and Proteins
NOD1 protein, human
NOD2 protein, human
Nod1 Signaling Adaptor Protein
Nod2 Signaling Adaptor Protein
Peptidoglycan