Abstract
Presented are the clinical data of 18 consecutive patients who were treated by IV recombinant tissue plasminogen activator (r-TPA) for suspected vertebrobasilar (VB) acute ischemia within 7 hours. The mean delay for treatment was 5 +/- 3.6 hours. Mean baseline NIH Stroke Scale score was 17 +/- 4. At 3 months, 10 patients were independent (modified Rankin Scale [mRS] score = 0 to 2), whereas 8 patients showed a poor outcome (mRs = 3 to 6). IV r-TPA in VB ischemia in a 7-hour window may be safe and efficient.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anticoagulants / therapeutic use
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Drug Therapy, Combination
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Female
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Fibrinolytic Agents / therapeutic use*
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Heparin / therapeutic use
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Humans
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Male
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Middle Aged
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Nadroparin / therapeutic use
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Platelet Aggregation Inhibitors / therapeutic use
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Recombinant Proteins / therapeutic use
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Severity of Illness Index
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Thrombolytic Therapy*
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Tissue Plasminogen Activator / therapeutic use*
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Tomography, X-Ray Computed
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Treatment Outcome
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Vertebrobasilar Insufficiency / diagnostic imaging
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Vertebrobasilar Insufficiency / drug therapy*
Substances
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Anticoagulants
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Fibrinolytic Agents
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Nadroparin
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Platelet Aggregation Inhibitors
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Recombinant Proteins
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Heparin
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Tissue Plasminogen Activator