CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl beta-carbolin-1-ones

Org Biomol Chem. 2004 Jun 7;2(11):1573-4. doi: 10.1039/b406046f. Epub 2004 May 10.

Abstract

An expedient synthetic route for 3-aryl beta-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the beta-carbolin-1-ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.