Aim: To provide the morphological evidence on participating in the adhesive function of human umbilical vein endothelial cells by CD226.
Methods: Human umbilical vein endothelial cells(HUVECs) were cultured and the effect of CD226 on the adhesion between activated HUVEC and activated PBMC were observed by Leica inverted microscope and scanning electron microscope.
Results: Fusion protein CD226/Ig could block the adhesion between activated HUVECs and activated PBMC markedly.
Conclusion: CD226 was a novel inducible adhesion molecule expressed on activated endothelial cells, which may possess important physiological and pathological function.