Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome

J Gen Virol. 2004 Jun;85(Pt 6):1485-1488. doi: 10.1099/vir.0.19717-0.

Abstract

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4-6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endogenous Retroviruses / genetics*
  • Genome, Human*
  • Humans
  • Terminal Repeat Sequences*
  • Virus Integration*