Bivalirudin-associated intracoronary thrombosis during gamma-brachytherapy and its experimental validation in acute swine model

Catheter Cardiovasc Interv. 2004 Jun;62(2):209-13. doi: 10.1002/ccd.20056.

Abstract

Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty. Cases of intracoronary thrombosis have been reported with beta-radiation when bivalirudin is used as an anticoagulant. We report two cases of intracoronary thrombosis with gamma-radiation when bivalirudin is used.

Publication types

  • Case Reports
  • Validation Study

MeSH terms

  • Aged
  • Angina, Unstable / diagnostic imaging
  • Angina, Unstable / therapy
  • Angioplasty, Balloon, Coronary
  • Animals
  • Anticoagulants / adverse effects*
  • Antithrombins / adverse effects*
  • Brachytherapy*
  • Coronary Angiography
  • Coronary Restenosis / diagnostic imaging
  • Coronary Restenosis / therapy
  • Coronary Thrombosis / chemically induced*
  • Coronary Thrombosis / diagnostic imaging
  • Female
  • Gamma Rays / therapeutic use*
  • Hirudins / adverse effects*
  • Hirudins / analogs & derivatives*
  • Humans
  • Male
  • Middle Aged
  • Peptide Fragments / adverse effects*
  • Recombinant Proteins / adverse effects*
  • Swine

Substances

  • Anticoagulants
  • Antithrombins
  • Hirudins
  • Peptide Fragments
  • Recombinant Proteins
  • bivalirudin