Synthesis and biological activities of cyclopropenone antibiotic penitricin and congeners

J Antibiot (Tokyo). 1992 Jul;45(7):1148-54. doi: 10.7164/antibiotics.45.1148.

Abstract

A number of derivatives of the cyclopropenone antibiotic penitricin have been synthesized by the reaction of metalated cyclopropenone acetals with electrophiles. Studies on the antimicrobial structure-activity relationships indicated that the penitricin skeleton, hydroxymethylcyclopropenone, is indispensable for antimicrobial activity. These compounds were also found to display cytotoxic activity.

MeSH terms

  • Bacteria / drug effects
  • Cyclopropanes / chemical synthesis
  • Cyclopropanes / pharmacology
  • Magnetic Resonance Spectroscopy
  • Methods
  • Microbial Sensitivity Tests

Substances

  • Cyclopropanes
  • penitricin