The implementation of intensity modulated radiotherapy (IMRT) for patients with prostate cancer in daily routine has been elaborated at our department. Our quality assurance (QA) concept is one method to pave the way for initiating IMRT treatments for starting institutions. A clinical quality assurance (CQA) procedure has been set-up for all patients before and throughout the course of radiotherapy. Simultaneously medical physicists established a physical quality assurance (PQA) concept that has been followed for all patients as well. Alternative CQA and PQA procedures are discussed. The literature is reviewed and discussed with special respect to quality assurance in IMRT of prostate cancer patients.