Alveolar adenoma of the lung: a clinicopathologic, immunohistochemical, and molecular study of an unusual case

Int J Surg Pathol. 2004 Apr;12(2):155-9. doi: 10.1177/106689690401200212.

Abstract

We describe an alveolar adenoma of the lung with 3 previously unreported findings, which expand both the clinical and the morphologic spectrum of this rare tumor: presentation as a cystic nodule, foci of mature adipocytes, and S-100 positivity of the mesenchymal cells. Furthermore, using a laser capture microdissection technique under microscope visualization, we analyzed multiple chromosomal loci in both the epithelial and mesenchymal components of the lesion, showing microsatellite alterations and loss of heterozygosity in the former but not in the latter.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / genetics
  • Adenoma / metabolism
  • Adenoma / pathology*
  • Adipocytes / metabolism
  • Adipocytes / pathology
  • Aged
  • DNA, Neoplasm / analysis
  • Humans
  • Lasers
  • Loss of Heterozygosity / genetics
  • Lung / diagnostic imaging
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology*
  • Male
  • Microdissection / instrumentation
  • Microsatellite Repeats
  • Polymerase Chain Reaction
  • Pulmonary Alveoli / metabolism
  • Pulmonary Alveoli / pathology*
  • S100 Proteins / metabolism
  • Thoracotomy
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • DNA, Neoplasm
  • S100 Proteins