Primary dural mucosa-associated lymphoid tissue-type lymphoma: case report and review of the literature

J Neurooncol. 2004 May;68(1):19-23. doi: 10.1023/b:neon.0000024704.70250.42.

Abstract

A 47-year-old Hispanic male presented with visual field disturbances, memory impairment, and a seizure. CT and MRI were consistent with meningioma. Both neurologic exam and routine laboratory tests were within normal limits. The patient underwent craniotomy and subtotal resection of the tumor. On H&E, the lesion was composed of a lymphoid mass with well-defined irregularly shaped follicles surrounded by a monomorphic population of small lymphocytes. Marginal zones stained for B-cell markers, CD20 and CD79a, one T-cell marker, CD43, and kappa light chains. While other markers did not stain the majority of tumor cells, they did identify other lymphoid and plasma cell elements. A diagnosis of marginal zone B-cell lymphoma of dura, mucosa-associated lymphoid tissue (MALT)-type (extranodal) was made. MALT-type lymphomas are unusual in the nervous system; this is the first such case reported in a male and serves to emphasize the wide diversity of presentation of a neoplasm originally described in the GI tract and thus far described in the CNS only in females.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antigens, CD / metabolism
  • Central Nervous System Neoplasms / pathology*
  • Dura Mater / pathology*
  • Humans
  • Immunophenotyping
  • Lymphoma, B-Cell, Marginal Zone / diagnosis*
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Male
  • Middle Aged

Substances

  • Antigens, CD