Abstract
Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Cyclopentanes / chemical synthesis
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Cyclopentanes / chemistry*
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Cyclopentanes / pharmacology*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Piper / chemistry*
Substances
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Antifungal Agents
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Cyclopentanes
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cyclopentenone